| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| VAG0515-100 | 7 days | 100 µg | $300.00 |
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| VAG0515-500 | 7 days | 500 µg | $1,200.00 | |||
| VAG0515-1 | 7 days | 1 mg | $1,920.00 |
Product Overview | |
| Name | Dengue Rapid Test |
|---|---|
| Description | |
| Dengue Antigen for Rapid Test Recombinant | |
| Synonyms | |
| Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1, dickkopf WNT signaling pathway inhibitor 1, Dickkopf 1 Homolog, Dickkopf Related Protein-1, Dickkopf-1 Like, Dickkopf-Like Protein 1, Dickkopf (Xenopus Laevis) Homolog 1, DKK-1. | |
| Introduction | |
| Dickkopf-related protein 1 (DKK1) antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by creating a ternary complex with the transmembrane protein KREMEN which promotes internalization of LRP5/6. DKKs have a significant role in vertebrate development, where they locally inhibit Wnt controlled processes for instance antero-posterior axial patterning, limb development, somitogenesis and eye formation. Furthermore, Dkks are involved in bone formation and bone disease, cancer and Alzheimer disease in Adults. | |
| Source | |
| HEK. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The DKK1 protein was lyophilized from solution containing 1x PBS, pH 7.4 . | |
| Stability | |
| Lyophilized DKK1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution DKK1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 97.0% as determined by analysis by SDS-PAGE and HPLC analysis. | |
| Amino acid sequence | |
| TLNSVLNSN IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH. | |
| Biological Activity | |
| The specific activity was determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized DKK1 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| Dengue Rapid Test is for research use only and not for use in diagnostic or therapeutic procedures. | |
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